EXERT Trial: Exercise Delays Cognitive Decline in Older Adults at Dementia Risk

April 24, 2025
EXERT Trial: Exercise Delays Cognitive Decline in Older Adults at Dementia Risk
  • The EXERT trial, involving nearly 300 sedentary older adults with mild cognitive impairment, compared the effects of exercise groups to those receiving standard care.

  • The social and intellectual stimulation from participating in the research itself may have contributed to the observed cognitive stability among participants.

  • The findings were published in two papers in 'Alzheimer's and Dementia: The Journal of the Alzheimer's Association' and underscore the importance of exercise for cognitive health.

  • The trial's design aimed to enhance community implementation potential by bringing exercise interventions closer to home for participants.

  • Participants in the study engaged in either moderate to high-intensity aerobic training or low-intensity stretching, balance, and range of motion activities three to four times a week for a full year under YMCA supervision.

  • Lead author Dr. Aladdin Shadyab highlighted the critical need for early intervention in individuals at high risk of developing Alzheimer's dementia, noting that approximately 16% of those with mild cognitive impairment progress to Alzheimer's each year.

  • The findings from the EXERT study revealed that cognitive function remained stable over 12 months in both exercise groups compared to those who received usual care without exercise.

  • Additionally, both exercising groups experienced less brain volume loss, particularly in the prefrontal cortex, which is essential for cognitive function.

  • Experts recommend at least 150 minutes of moderate exercise per week, emphasizing that consistency is more crucial than intensity for cognitive health.

  • Notably, EXERT collaborated with the YMCA to facilitate community-based exercise interventions, making it one of the first large clinical trials of this type.

  • Previous studies on the benefits of exercise for cognitive health have been inconsistent, highlighting the need for large, well-designed trials like the EXERT study.

  • These results suggest that regular exercise, even at lower intensities, could significantly aid in delaying cognitive decline for older adults at high risk of dementia.

Summary based on 5 sources


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