Study: Brain Aging Accelerates at 44; Ketone Drinks May Offer Early Intervention Benefits

March 26, 2025
Study: Brain Aging Accelerates at 44; Ketone Drinks May Offer Early Intervention Benefits
  • The analysis revealed that certain brain regions aged faster than others, particularly those that depend heavily on insulin for sugar uptake.

  • Brain scans from the study indicated that disruptions in blood flow and electrical firing between brain regions, which are indicative of aging, began to intensify around this age.

  • The study utilized brain scans from 19,300 individuals aged 18 to 90 to analyze brain networks and their aging patterns.

  • In a small trial, participants aged 20 to 79 who consumed a ketone drink experienced reduced brain network disruptions compared to those who consumed a sugary drink.

  • Despite these promising results, the research highlights the need for further studies to assess the long-term effects of ketone supplementation on brain aging.

  • Lead researcher Lilianne Mujica-Parodi highlighted the unexpected early onset of accelerated brain aging starting in the 40s.

  • A recent study published in the journal PNAS reveals that brain aging accelerates significantly around age 44, with effects peaking at age 67.

  • These findings indicate that brain aging is associated with insulin resistance, where cells require more insulin to manage blood sugar levels.

  • The research suggests that ketone supplements might help mitigate certain aspects of brain aging by providing an alternative fuel source when sugars are insufficient.

  • Notably, the most significant benefits of the ketone drink were observed in participants aged 40 to 59, suggesting potential advantages for early intervention.

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