Neutrophil-to-Lymphocyte Ratio: Key Predictor of Poor Outcomes in Heart Failure and Atrial Fibrillation

August 13, 2024
Neutrophil-to-Lymphocyte Ratio: Key Predictor of Poor Outcomes in Heart Failure and Atrial Fibrillation
  • In heart failure, an elevated neutrophil-to-lymphocyte ratio (NLR) is correlated with poor outcomes, highlighting its potential as a risk stratification tool.

  • Research indicates that NLR can serve as an independent predictor for various cardiovascular disease (CVD) outcomes, necessitating its integration into clinical practice for improved risk assessment and management.

  • The study found that NLR was significantly higher in patients who died during hospitalization compared to survivors, establishing it as an independent predictor of in-hospital mortality for atrial fibrillation (AF) patients.

  • Atrial fibrillation is the most common cardiac arrhythmia, with its prevalence rising over the past two decades, contributing to increased morbidity and mortality.

  • Cardiovascular diseases are the leading cause of death globally, exacerbated by unhealthy lifestyles and metabolic comorbidities.

  • The study highlighted the importance of oxidative stress and inflammation in the development of postoperative AF and acute kidney injury following surgery.

  • A study assessed plasma nitrite and serum interleukin-6 levels in cardiac surgical patients to understand their role in predicting postoperative complications.

  • Including plasma nitrite levels improved the predictive model for postoperative atrial fibrillation, increasing the area under the curve from 0.77 to 0.81.

  • Postoperative atrial fibrillation and acute kidney injury are significant complications after cardiac surgery, with incidences reaching up to 40%.

  • A history of diabetes was linked to the occurrence of acute kidney injury, with preoperative interleukin-6 levels enhancing the prediction model for AKI.

  • Future research is necessary to further validate the clinical utility of NLR and enhance prediction models for mortality in atrial fibrillation patients.

Summary based on 3 sources


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