Breakthrough Study: Blocking IL-11 Protein Extends Mice Lifespan by 25%, Paves Way for Human Anti-Aging Therapies
July 18, 2024
Scientists from Duke-NUS Medical School, the Medical Research Council Laboratory of Medical Science, and Imperial College London conducted a study on the protein interleukin-11 (IL-11).
Inhibiting IL-11 can increase the healthy lifespan of mice by nearly 25%.
IL-11 deletion or anti-IL-11 treatment improves metabolism, muscle function, and reduces aging biomarkers in mice.
The research is funded by the National Medical Research Council (Singapore) and the Medical Research Council (UK).
The study is currently in clinical trials for fibrotic lung disease.
Potential anti-aging therapies for humans could emerge from this research.
Challenges include gaining approval for anti-aging drugs and securing funding for further clinical trials.
Summary based on 14 sources
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Sources
BBC News • Jul 17, 2024
Ageing: 'Supermodel granny' drug extends life in animal tests
Nature • Jul 17, 2024
Inhibition of IL-11 signalling extends mammalian healthspan and lifespan
Nature • Jul 17, 2024
Mice live longer when inflammation-boosting protein is blocked
The Telegraph • Jul 17, 2024
Scientists discover anti-ageing holy grail that can stop cancer – and grey hair – in its tracks