Additionally, the newsletter explores the potential of repurposing previously discarded drugs to aid in remyelination, which could be beneficial for conditions such as multiple sclerosis and cognitive decline associated with aging.

Innovative strategies targeting the Rho-GTPase family are also discussed, aiming to suppress cancer metastasis while managing the delicate balance of effective treatment and minimal side effects.

Research into reprogramming cancer cells back to normal states shows promise, particularly in colon cancer, through the application of systems biology to identify key molecular switches.

The evolving concept of the 'NAD World' is examined, linking NAD levels to aging processes, although researchers acknowledge that tangible therapeutic outcomes are still elusive.

The latest issue of the Fight Aging! newsletter, set to publish on February 17, 2025, emphasizes research and commentary aimed at combating age-related diseases through modern medicine.

One key article discusses how stalled production of amyloid-β may play a significant role in Alzheimer's disease, shifting the focus from mere amyloid accumulation to subsequent processes like neuroinflammation and tau aggregation.

Another article highlights the connection between gastrointestinal dysfunction and neurodegenerative diseases, particularly noting the influence of gut microbiomes on the progression of Parkinson's disease.

In the broader context of longevity, Reason, founder of Fight Aging! and Repair Biotechnologies, provides consulting services that connect investors with entrepreneurs in the longevity industry.

Overall, this issue covers a range of critical topics, including stalled amyloid-β production in Alzheimer's, drug repurposing for remyelination, and the intricate relationship between gut health and synucleinopathies.