Recent research investigates anabolic resistance in older males, particularly focusing on its role in sarcopenic obesity, which is a growing concern as the population ages.

The study highlights the urgent need for effective interventions to combat sarcopenic obesity in older adults, emphasizing the importance of high-quality protein supplementation combined with exercise.

Conducted at McMaster University Medical Centre, the research involved a randomized clinical trial assessing predictors of muscle mass adaptation over three months, utilizing a combination of resistance exercise and multi-ingredient supplementation.

A subgroup analysis compared two types of protein-based multi-ingredient supplements: collagen peptides with safflower oil (PLA) and a higher quality whey/casein blend (M5).

Results indicated that the M5 group experienced significantly greater improvements in lean mass, body fat ratios, strength, and overall performance compared to the PLA group, suggesting a superior anabolic response.

Bone turnover markers revealed that only the M5 group showed increased bone formation, underscoring the critical role of protein quality in maintaining musculoskeletal health.

The study identified obesity and a Global Risk Index for metabolic syndrome (MetS) as the strongest predictors of gains in lean mass and muscle-to-body fat ratios, demonstrating negative correlations with treatment response.

Moreover, the findings suggest that obesity and MetS significantly impair the anabolic response to both exercise and supplementation, highlighting the necessity for targeted nutritional strategies for older adults.

The clinical trial was registered under NCT03536871 and received funding from the Canadian Institutes of Health Research (CIHR), ensuring a robust framework for the study.