Changes in immune cell composition were noted, with increased levels of eosinophils and CD8 T cells, although some immune cells initially decreased before stabilizing.

While no overall reduction in inflammatory markers such as IL-6 or CRP was observed, some specific markers related to liver and intestinal health showed potential improvement.

DNA methylation analysis revealed over 1,600 differentially methylated sites associated with genes involved in stress response and inflammation.

A recent clinical trial conducted by SRW Laboratories evaluated the effects of the Cel System, which comprises three nutraceutical formulas, on biological aging and physiological performance.

The study found that participants aged 54 to 84 experienced a reduction in biological age and improvements in various health markers over a 12-month period.

Specifically, results indicated a mean biological age reduction of 5.71 years according to the SystemsAge clock, with notable reductions observed in other epigenetic clocks.

Participants also demonstrated enhancements in muscle strength, mobility, and body composition, including decreases in weight, BMI, and waist circumference.

Future research should focus on randomized controlled trials with larger cohorts to isolate the effects of individual supplement components and assess long-term health outcomes.

However, the study faced limitations due to its single-arm design, lack of placebo control, and small sample size, complicating the attribution of results solely to the supplements.

Despite these limitations, the findings suggest a promising avenue for non-pharmaceutical approaches to enhancing healthspan, pending further validation.