The Global Healthspan Summit 2025, organized by Hevolution Foundation, took place in Riyadh, Saudi Arabia, attracting over 3,000 attendees, making it the largest longevity conference globally.

Founded three years ago and heavily funded by Saudi Arabia, Hevolution Foundation emphasizes healthspan over mere longevity, advocating for the desire to live healthy and functional lives.

Hevolution's CEO, Dr. Mehmood Khan, highlighted the growing importance of shifting the conversation from lifespan to healthspan, noting that half of physicians now receive inquiries about these topics from patients.

Dr. Felipe Sierra, Hevolution's Chief Scientific Officer, stressed the need for a new understanding of aging that focuses on health and resilience rather than just the absence of disease.

Hevolution has rapidly emerged as a leading funder in geroscience, investing over $400 million in research and collaborating with over 250 scientists across 200 labs.

A panel on mammalian longevity explored comparative biology, with researchers examining genes from long-lived species to uncover mechanisms that could extend both lifespan and healthspan in humans.

Dr. Elena Sergeeva discussed the role of bioelectricity in aging, explaining how bioelectric signals can influence cell behavior and may be manipulated for regenerative medicine.

The summit highlighted the significance of biomarkers of aging, with Dr. Vadim Gladyshev and Dr. Steve Horvath presenting advancements in developing accurate aging clocks.

Dr. Steve Horvath introduced GrimAge, a methylation clock that predicts healthspan and mortality, showcasing its potential to inform treatments and interventions based on individual biological responses.

Alan A. Cohen proposed that focusing on intrinsic health rather than aging directly could provide a clearer path for interventions, underscoring the need for a comprehensive understanding of health metrics.