The Hippo pathway is a kinase cascade that interacts with various intracellular signals to regulate downstream transcription factors and maintain cellular homeostasis.

Recent findings suggest a correlation between the Hippo pathway and cellular senescence, which is crucial for maintaining tissue homeostasis.

Cellular senescence acts as a defense mechanism, promoting cell cycle arrest to protect against stress and damage while preventing aging-related diseases.

YAP and TAZ, factors associated with the Hippo pathway, are linked to the regulation of cellular senescence.

Researchers are studying the inhibition of the Hippo pathway as a potential basis for regenerative therapies.

These findings may pave the way for new tissue regeneration therapies and drugs aimed at rejuvenation.

However, aberrant activation of the Hippo pathway can cause significant stress, leading to diseases such as cancer and immune disorders.

Moreover, the accumulation of senescent cells can contribute to the progression of cancer and other age-related diseases.

This review highlights the relationship between aging and the Hippo pathway, providing insights into aging mechanisms and age-related disease development.