The PATH initiative focuses on harmonizing health datasets, identifying chronic disease subtypes, and creating non-invasive monitoring tools, supported by an AI-driven recommendation engine for personalized health strategies.

This project aims to utilize advanced analytics and AI to predict and prevent chronic diseases in individuals aged 50 and older, collecting crucial data before significant health declines occur.

Both programs aim to identify early health changes related to aging and develop diagnostic tools and therapies to address age-related conditions.

ARPA-H Director Dr. Renee Wegrzyn emphasizes the importance of targeting non-disease-related aging effects, such as declines in memory and muscle strength, through innovative research.

Dr. Andrew Brack, who is leading the PROSPR program, highlights the goal of compressing frailty and disability into a shorter duration at the end of life.

The Advanced Research Projects Agency for Health (ARPA-H) has launched the PROactive Solutions for Prolonging Resilience (PROSPR) program, aimed at enhancing the healthspan of Americans.

In conjunction with PROSPR, ARPA-H is also funding the Personalized Analytics for Transforming Health (PATH) project, which is led by the Buck Institute and Phenome Health, with a budget of up to $52 million over four years.

The PROSPR initiative focuses on improving quality of life by reducing age-related diseases and disabilities, shifting the emphasis from merely prolonging life to enhancing the years lived in good health.

To achieve these goals, the project will employ wearable technology and digital tools to track disease trajectories, aiming to revolutionize healthcare with data-driven insights.

ARPA-H cites a potential $29 billion annual savings for the US economy from even a minimal extension of healthspan, alongside an anticipated $80 billion annual economic boost.

The PROSPR program will invite proposals from experts in various fields, including wearable technology, data science, and drug development, with multiple awards expected based on submission quality.

Buck CEO Dr. Eric Verdin expressed excitement about the potential impact of PATH on healthy aging through foundational data and analytics.