A recent narrative review synthesizes current evidence linking the hallmarks of aging with diagnosed sarcopenia in humans.

Sarcopenia, a prevalent muscle disease associated with aging, leads to various adverse health outcomes.

Key features of sarcopenia include energy imbalance and mitochondrial dysfunction, which are crucial for understanding its development.

The Hallmarks of Aging framework provides valuable insights into the physiopathology of sarcopenia.

Among the twelve hallmarks of aging, significant associations have been identified between sarcopenia and mitochondrial dysfunction, epigenetic changes, deregulated nutrient sensing, and altered intercellular communication.

Impaired mitochondrial energy production and changes in circulatory markers highlight the connection between aging and sarcopenia biology.

Despite these insights, the biological pathways connecting aging and sarcopenia remain not fully understood, indicating a pressing need for further research.

Preliminary evidence also suggests potential links between sarcopenia and genomic instability or stem cell exhaustion, although these findings are currently limited.