As Japan faces challenges related to decreased muscle strength in its super-aging society, the research addresses a critical health concern affecting quality of life.

Nitration specifically affects tyrosine amino acids on the HGF protein at positions 198 and 250, diminishing its effectiveness.

The team identified two promising antibody candidates, 1H41C10 and 1H42F4N, designed to prevent the nitration of HGF.

These antibodies show promise for developing treatments aimed at age-related muscle atrophy and other conditions associated with impaired muscle regeneration.

Antibody 1H42F4N effectively inhibited nitration at position 198, while 1H41C10 blocked nitration at both sites without disrupting HGF's activity.

In response to these findings, researchers from Kyushu University have developed a new antibody targeting HGF, which is essential for muscle development and repair.

A recent study published in the journal Aging Cell highlights the potential of hepatocyte growth factor (HGF) in treating age-related muscle issues.

Led by Professor Ryuichi Tatsumi, the research reveals that HGF loses its activity through nitration, a process that occurs as people age.

Despite increased life expectancy, age-related health issues, particularly muscle atrophy, remain a significant concern for the aging population.

Muscle regeneration is crucially dependent on satellite cells, which are activated by HGF during training or injury.

Further research is necessary to explore the therapeutic applications of HGF in addressing various health issues related to aging.