Moreover, SIRT1 activity is essential for maintaining thyroid hormone levels; its absence can lead to decreased thyroxine secretion and subsequent metabolic imbalances.

Vitamin D3 supplementation has been linked to increased SIRT1 expression, which promotes cardiovascular health and reduces senescence-related changes in endothelial cells.

Natural SIRT1 activators, such as resveratrol, curcumin, and Buyang Huanwu Decoction, show promise in addressing age-related hormonal changes, although their effectiveness is limited by low bioavailability.

A recent review explores the critical role of SIRT1 in hormonal regulation across various hypothalamic-pituitary axes, including the thyroid, adrenal, gonadal, and liver axes.

SIRT1 is identified as a key regulator of hormonal pathways and homeostasis, significantly influencing processes related to oxidative stress, immune response, and metabolism.

The hypothalamic-pituitary-liver axis, which is regulated by SIRT1, plays a vital role in the secretion of growth hormone and insulin-like growth factor 1, thereby impacting metabolism and aging-related diseases.

Additionally, SIRT1 is crucial for the hypothalamic-pituitary-gonadal (HPG) axis, affecting reproductive health and hormone levels, particularly during the aging process.

SIRT1 also influences the hypothalamic-pituitary-adrenal (HPA) axis, enhancing the production of corticotropin-releasing hormone (CRH) and regulating the stress response.

As individuals age, hormonal changes occur that heighten the risk of chronic diseases, including cardiovascular, neurodegenerative, and metabolic disorders.

In postmenopausal women, the decline in estrogen levels is associated with increased cardiovascular risks, and SIRT1 modulation can impact estrogen signaling and overall cardiovascular health.

Research indicates that SIRT1 activation may help mitigate insulin resistance and enhance insulin secretion, presenting potential therapeutic strategies for age-related diabetes and metabolic disorders.