Recent research has focused on the extraction of bioactive phenolic compounds, specifically ellagic acid and punicalagins, from pomegranate peel using natural deep eutectic solvents (NaDES) combined with ultrasound-assisted extraction (UAE) and pressurized liquid extraction (PLE).

The study emphasizes the need for environmentally friendly alternatives to traditional solvents, showcasing the role of deep eutectic solvents (DESs) in achieving sustainable extraction processes.

Additionally, the research suggests that MAE and UAE techniques can enhance efficiency and sustainability in the cocoa industry, where significant waste is generated.

For every kilogram of cocoa powder produced, approximately ten kilograms of waste, including cocoa bean shells (CBSs), are generated, presenting an opportunity for resource recovery.

Cocoa bean shells, a by-product of cocoa production, are identified as a promising source of bioactive compounds, particularly polyphenols and fibers.

The study evaluates the efficiency of UAE and MAE for extracting phenolic compounds from CBSs, demonstrating their potential as effective methods compared to traditional extraction techniques.

Both MAE and UAE offer eco-friendly alternatives to conventional organic solvent-based extraction methods, enhancing yields and reducing extraction times.

The research highlights the importance of recovering bioactive substances for applications in nutraceuticals, pharmaceuticals, and cosmetics.

Furthermore, the study explores the partitioning of phenolic compounds in aqueous two-phase systems (ATPS) using acetonitrile and DES formed from choline chloride and carbohydrates.

The findings suggest that DES-based ATPS can effectively extract and purify valuable phenolic compounds due to their biocompatibility and environmentally friendly nature.

NaDES are biodegradable, non-toxic, and cost-effective alternatives to traditional organic solvents, making them suitable for environmentally friendly extraction processes.

Results from HPLC-DAD analysis indicate that NaDES extraction methods significantly improve the recoveries of ellagic acid and punicalagins compared to traditional water-based extraction methods.