The film's synopsis reveals that the drug in 'The Substance' generates a younger version of a person, with a strict time-sharing rule between the two, further complicating the narrative.

Demi Moore, a prominent actress in Hollywood for four decades, has faced significant challenges in earning respect as she ages within the industry.

Now 61, Moore recently reflected on Hollywood's treatment of women over 40 during an interview with Michelle Yeoh, discussing the scrutiny she faced regarding her appearance.

Acknowledging the importance of vulnerability in her role, Moore worked closely with director Coralie Fargeat to ensure authenticity in the film's portrayal of nudity and rawness.

Both Moore and Yeoh are committed to challenging Hollywood's limitations on women's roles and perceptions of beauty, advocating for the acceptance of older women as sexy and desirable.

Yeoh echoed Moore's sentiments, highlighting that Hollywood often limits roles for women over 45 to either mothers or unappealing characters.

She specifically recalled the public attention surrounding her bikini scene in 'Charlie's Angels: Full Throttle,' which contributed to her feelings of identity struggle post-film.

Moore emphasized that the film explores themes of aging and societal pressures, illustrating the internal violence women impose on themselves due to unrealistic ideals.

In her upcoming horror film, 'The Substance,' Moore portrays Elisabeth Sparkle, a fading Hollywood beauty who uses an experimental drug to regain her youth, facing severe side effects.

Set to be released in theaters on September 20, 2024, 'The Substance' explores the violence women do to themselves through societal conditioning.

Moore expressed her excitement about the film's positive reception at Cannes, where it received a 13-minute standing ovation, leading some to label it a 'comeback' for her.

Moore described the film's exploration of self-perception and the psychological violence women inflict on themselves through societal ideals, which resonates deeply with her own experiences.