Groundbreaking research from the University of Rochester and the University of Copenhagen reveals a new pathway in the trigeminal nerve explaining why migraines are often one-sided.

The study, led by neurobiologist Maiken Nedergaard, found that proteins released during aura trigger headaches by activating pain-signaling nerves in the trigeminal ganglion.

This discovery challenges traditional theories about migraine pathophysiology and offers new insights into migraine mechanisms.

Researchers identified 12 substances, including CGRP, capable of activating sensory nerves, providing potential targets for medication development.

The findings offer hope for the one in ten people who suffer from migraines and pave the way for personalized migraine therapies in the future.

This research sheds light on the development of targeted treatments for migraine and other headache disorders.