Scientists utilized a mountain rescue dog named Shola with progressive retinal atrophy (PRA) to create a DNA test targeting the genetic variant causing the eye condition in English Shepherd Dogs (ESDs).

A team led by the University of Cambridge identified the genetic mutation causing PRA in ESDs, leading to the development of a DNA test to detect the disease.

This DNA test allows for breeding decisions to prevent passing on the faulty gene to puppies, ultimately aiming to eliminate PRA from the breed.

The genetic mutation is recessive, requiring two copies for blindness to occur, making carriers unaffected but able to pass it on.

Shola's offspring have been confirmed free of PRA, safeguarding their training and capabilities.

The research aims to eradicate PRA from the ESD breed and prevent its occurrence through strategic breeding practices.

A commercial genetic testing service now offers a test for PRA in ESDs, allowing breeders to ensure healthy puppies.

The study of PRA in dogs could provide insights into the human version of the disease and potential gene therapy targets in the future.

The research emphasizes the impact of breeding practices on dog health and highlights the importance of genetic screening and selective breeding in managing inherited eye diseases in dogs.