Researchers presented promising results for a new male contraceptive gel called NES/T at the ENDO 2024 conference.

NES/T combines segesterone acetate and synthetic testosterone.

The gel effectively reduced sperm production within eight weeks for 86% of participants, with some reaching effective sperm count by week 15.

This method showed faster suppression compared to previous hormone-based methods, averaging less than eight weeks.

Testosterone levels remained stable, and no adverse side effects were reported.

The gel is applied daily to the shoulder blades and is under further evaluation for effectiveness, safety, acceptability, and reversibility.

The development of a rapid and reliable male contraceptive addresses an important unmet need in the field.