Biomedical engineers at the University of Melbourne have developed a groundbreaking 3D bioprinting system capable of creating human tissue structures with remarkable speed and accuracy.

This innovative optical-based system can print cellular structures in seconds, making it approximately 350 times faster than traditional slow, layer-by-layer methods.

One of its key features is the ability to print directly into standard lab plates, which enhances cell survival rates and maintains the integrity of printed structures without the need for physical handling.

The new system overcomes limitations faced by current bioprinters, which struggle with the natural alignment of cells, by utilizing acoustic waves from vibrating bubbles to improve cell organization.

Associate Professor David Collins emphasized that this technology not only improves print speed but also allows for precise cell positioning, a critical factor in accurately replicating human tissues.

The bioprinter significantly enhances the ability to predict drug responses and develop new treatments, potentially reducing the reliance on animal testing.

It can replicate a variety of human tissues, including soft brain tissue and rigid materials like cartilage and bone, making it a powerful tool for cancer researchers in drug discovery.

The research team, which includes around 60 collaborators from prestigious institutions such as the Peter MacCallum Cancer Centre and Harvard Medical School, has received positive feedback on this technology.

PhD student Callum Vidler noted that the technology has generated significant excitement within the medical research community, effectively bridging the gap between laboratory research and clinical applications.

The findings of this research were published in the October 30, 2024 issue of Nature, highlighting the substantial advancements in speed, precision, and consistency of bioprinting.