Professor's Fetal DNA Discovery Revolutionizes Prenatal Testing, Paving Way for Non-Invasive Health Diagnostics

February 22, 2025
Professor's Fetal DNA Discovery Revolutionizes Prenatal Testing, Paving Way for Non-Invasive Health Diagnostics
  • Interestingly, Lo's innovative approach was inspired by a casual observation related to instant noodles, which ultimately led to significant advancements in pathology.

  • Professor Dennis Lo's groundbreaking discovery of fetal DNA in maternal plasma has revolutionized prenatal testing, eliminating the need for invasive procedures like amniocentesis for approximately 10 million expecting mothers globally.

  • His research led to the development of the T21 test, which screens for Down syndrome and other genetic disorders, available since 2011 at a cost ranging from HK$4,500 (US$578) to HK$8,000 in Hong Kong.

  • The T21 test has gained widespread adoption, being utilized by women in 90 countries, showcasing its significant impact on prenatal healthcare worldwide.

  • In recognition of his contributions, Lo was awarded the inaugural Future Science Prize in Life Sciences in 2016, marking a pivotal moment in the field of medical science.

  • Additionally, Lo emphasized that aging alters DNA formats, which allows for the application of epigenetics as a biological clock in medical research.

  • Looking ahead, Lo's research suggests that future blood tests could diagnose a range of health conditions, including neurodegenerative diseases like Alzheimer's, by utilizing circular nucleic acids and epigenetics.

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