This study was a collaborative effort involving multiple researchers from the University of Pittsburgh and UPMC, with financial backing from the National Institutes of Health and the German Research Foundation.

Researchers have delved into the science of scratching, examining its impact on inflammation and overall skin health.

Despite the fact that scratching exacerbates skin irritation, mast cells are also crucial in the body's defense against bacterial infections.

Common symptoms associated with contact dermatitis include an itchy rash, darker leathery patches, dry skin, bumps or blisters, and tenderness.

When activated, mast cells release histamine, which contributes to increased swelling and redness during allergic reactions.

The insights gained from this research could pave the way for new treatments aimed at various inflammatory skin conditions, such as rosacea and urticaria.

Interestingly, scratching an itchy rash can produce a pleasurable sensation by inducing mild pain, which distracts the brain from the itch and promotes the release of serotonin, often referred to as the 'feel-good hormone'.