A team from the University of Pennsylvania and the University of Leeds discovered a multi-protein complex called 55LCC that regulates the pausing or stopping of DNA replication.

The research focused on the 'lagging strand' of DNA replication, which has been less understood in the scientific community.

The 55LCC complex is crucial for unfolding the replication complex to prevent replication from getting stuck and causing cell division to cease, leading to genome stability issues.

Mutations in the enzymes that comprise 55LCC are linked to severe neurodevelopmental syndromes, suggesting the discovery has direct clinical relevance.

The implications of 55LCC may extend to protein recycling processes, which are essential for cellular health.

Continued research aims to understand how 55LCC is activated and its broader impact, representing a significant advancement in the field of DNA replication and human health.