Drafted as the 32nd overall pick in the first round by the Saints in 2017, Ramczyk quickly became a starter, playing in all 101 games of his career and earning first-team All-Pro honors in 2019.

Throughout his career, Ramczyk faced the Tampa Bay Buccaneers 12 times, achieving a record of 7 wins and 5 losses, although he lost his last three matchups against them.

During his tenure, Ramczyk helped the Saints secure the NFC South title and achieve at least 11 wins in each of his first four seasons, contributing to one of the best offensive lines in the league.

Despite his struggles, Ramczyk's impact was significant, as he played a crucial role in the team's success, including four consecutive playoff appearances from 2017 to 2020.

With Ramczyk's retirement, the Saints are expected to rely on second-year player Taliese Fuaga to take over the tackle position.

Ramczyk's retirement comes shortly after fellow tackle Terron Armstead announced his own retirement, marking the end of an era for the Saints' offensive line.

Ryan Ramczyk, a three-time All-Pro right tackle for the New Orleans Saints, announced his retirement from the NFL on April 18, 2025, after seven seasons with the team.

His decision to retire follows a challenging period marked by knee cartilage degradation, which limited his play in recent seasons and caused him to miss the entire 2024 season.

His last game was a victory against the Carolina Panthers on December 10, 2023.

Reflecting on his unconventional journey to the NFL, Ramczyk acknowledged moments of doubt and highlighted how the road less traveled can lead to fulfilling destinations.

In his farewell message, Ramczyk expressed gratitude for his career, thanking coaches, teammates, and Saints fans, and looked forward to spending more time with his family, especially his two sons.

His football journey began after attending technical college and playing at UW-Stevens Point, where he became a standout tackle, eventually earning All-American honors.