Niko Tsakiris, the 7th ranked player from San Jose Earthquakes, faces new challenges under head coach Bruce Arena and could miss portions of the season due to U20 national team commitments.

Nathan Ordaz, a 21-year-old forward with LAFC, has shown promise in preseason and could break into the starting lineup after impressive displays in training and matches.

Brooklyn Raines, ranked 8th with Houston Dynamo, is looking to establish himself as a consistent player after playing only 413 minutes last season.

Brazilian youth international Matheus Nascimento, a recent Copa Libertadores champion, joined MLS Galaxy on loan for the 2025 season, aiming to further his development.

In 2025, Major League Soccer (MLS) is set to showcase a wealth of young talent, with Cavan Sullivan of Philadelphia Union making headlines as the league's youngest player at just 14 years and 293 days old.

Peyton Miller, the 2nd ranked player from New England Revolution, is a promising fullback and part of last year’s U.S. Under-17 World Cup squad, potentially eyeing a transfer in January 2026.

Dylan Borso from Chicago Fire, ranked 10th, is a creative midfielder who made an impact at Wake Forest but is currently sidelined with an injury for up to four months.

This season, over 50 players in the U22 category are expected to thrive in MLS, with several key figures poised to capture attention and potentially influence transfer activity.

Established young stars like Diego Luna and Jack McGlynn have already garnered fan support, while promising talents such as Obed Vargas and Nathan Saliba are also making waves in North America.

Nathan Saliba has emerged as a key player for CF Montréal, earning over 3,500 MLS minutes and being called up to the Canadian national team after impressive performances in the league.

Julian Hall, ranked 3rd and playing for New York Red Bulls, had a standout year and is likely to transition to a striker role in MLS NEXT Pro.

Cavan Sullivan, ranked 1st from Philadelphia Union, is highlighted as the standout prospect due to his work ethic and versatility in the attacking third.