The 2025 MLB Opening Day marks the beginning of the regular season for most teams, following a two-game series in Japan between the Cubs and Dodgers.

The Los Angeles Angels are determined to end their record-long postseason drought, which has persisted since 2014, by enhancing their roster with several veterans, including Opening Day starter Yusei Kikuchi.

However, the Angels will be without third baseman Anthony Rendon for the entire season due to hip surgery, and franchise star Mike Trout is transitioning to right field to improve his health.

The Angels will kick off their season against the Chicago White Sox at 4:10 p.m. ET at Rate Field in Chicago, Illinois, with the game available for live streaming on fubo and MLB.TV.

The White Sox, on the other hand, are undergoing a significant rebuild after a dismal 2024 season in which they lost a modern record of 121 games, including the recent trade of their ace Garrett Crochet to the Red Sox.

For the 2025 season, Chicago's focus is on developing young talent rather than seeking immediate success, with players like Sean Burke, Miguel Vargas, and Jonathan Cannon expected to play pivotal roles in the team's future.

As for the betting odds, the Angels are positioned at +100 while the White Sox are at -120, with an over/under set at 8.5 runs according to Caesars Sportsbook.