Pfizer Halts Obesity Pill Danuglipron Amid Liver Injury Concerns, Faces Market Setback

April 14, 2025
Pfizer Halts Obesity Pill Danuglipron Amid Liver Injury Concerns, Faces Market Setback
  • Chris Boshoff, Pfizer's chief scientific officer, expressed disappointment over this decision but emphasized the company's ongoing commitment to innovative medicines.

  • Pfizer is set to report its first-quarter earnings later this month, as it looks to stabilize its share price and diversify its portfolio.

  • The global market for obesity medications is booming, projected to reach $130 billion by the end of the decade, making successful products critical for pharmaceutical companies.

  • Following the announcement of danuglipron's discontinuation, Pfizer's stock initially fell over three percent in pre-market trading but later rose slightly.

  • Despite the popularity of obesity medications, many patients face challenges accessing them due to supply shortages and inconsistent insurance coverage.

  • Although recent studies on danuglipron met key benchmarks for efficacy and tolerability, the company decided to discontinue its development.

  • Pfizer has announced the halt of its obesity treatment pill, danuglipron, due to a reported potential drug-induced liver injury in a trial participant.

  • Pfizer's decision to halt research on danuglipron followed a thorough review of clinical data and consultations with regulators.

  • This is not Pfizer's first setback in the obesity treatment arena, as the company had previously discontinued a twice-daily version of the drug due to patient tolerance issues.

  • Other pharmaceutical companies, including Novo Nordisk and Eli Lilly, are also developing oral weight-loss pills, indicating a competitive landscape in this market.

  • This setback is particularly significant for Pfizer as it strives to compete in the lucrative obesity medication market against established products from Novo Nordisk and Eli Lilly.

  • Analysts predict the GLP-1 market could exceed $150 billion by the early 2030s, with oral medications potentially capturing a substantial share.

Summary based on 16 sources


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