Spanish researchers at CNIC have linked APOE4 gene variant to increased risk of subclinical atherosclerosis in middle age.

Conversely, APOE2 variant is associated with a protective effect against early atherosclerotic cardiovascular disease.

The study of over 4000 asymptomatic individuals highlighted the importance of controlling LDL cholesterol and triglyceride levels, especially for APOE2 allele's protective benefits.

Those carrying APOE4 have the highest cardiovascular disease risk, primarily due to elevated LDL cholesterol levels.

Genetic testing for APOE variants could enhance cardiovascular risk prediction and inform more targeted risk management strategies.

The research acknowledges the necessity of addressing ethical concerns related to genetic testing for disease prediction.

Funding for the research was provided by the European Regional Development Fund and the European Social Fund.